LNP stands for “Lipid Nanoparticle.” LNP lipids are a type of lipid nanoparticle that are commonly used in drug delivery systems. They are composed of a mixture of lipids, which form a shell around a hydrophobic drug molecule, allowing it to be transported through the bloodstream and delivered to target cells. LNP lipids typically contain a cationic lipid, which helps the nanoparticle to bind to negatively charged cell membranes, as well as other neutral or anionic lipids. They are often used to deliver nucleic acid-based therapeutics, such as siRNA or mRNA, to target cells, and have shown promise in the treatment of a variety of diseases, including cancer and genetic disorders. There are many different types of lipids that can be used in LNP formulations, but some commonly used LNP lipids include: DSPC (1,2-distearoyl-sn-glycero-3-phosphocholine): a neutral lipid that provides stability to the LNP and helps to maintain its structure. Cholesterol: another neutral lipid that is often used in LNP formulations to enhance stability and reduce clearance by the immune system. PEG-lipids (polyethylene glycol-lipids): hydrophilic lipids that can be added to the LNP to increase its circulation time in the bloodstream and reduce immune system recognition. DOTAP (1,2-dioleoyl-3-trimethylammonium-propane): a cationic lipid…
All raw materials for mRNA IVT reaction, NTPs, modified bases, capping reagents, enzymes, purification beads and cDNA/plasmid synthesis reagents
All you need for Oligonucleotide synthesis. Nucleosides, Phosphoramidites, custom nucleotides and nucleosides
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